Prior to the course, participants will be invited to describe an investigation from their own work,

that they will be encouraged to use in the practical exercises wherever possible

Before the course, participants should prepare their computer and software environment using the following advice for

R usershere

Stata usershere(ADO and HLP files for Session 5)here

These documents also explain where to store the data sets which should be downloaded from here and unzipped.

- Lecture 1.1 Disease occurrence and risk (review)
- Lecture 1.2 Sources of bias
- Lecture 1.3 Review of epidemiological tables
- Exercise 1.1 Description of own work in terms of design and sampling scheme
- Exercise 1.2 Pencil & paper, openepi.com, Stata/R. solutions are here
- Lecture 2.1 From tables to logistic regression models
- Lecture 2.2 The role of matching in cohort and case-control studies
- Lecture 2.3 Analysis of matched data.
- Exercise 2.1 Logistic regression. solutions are here
- Exercise 2.3 Exercise 2.3: Conditional logistic regression. solutions are here
- Lecture 3.1 Introducing time: inclusive, exclusive and concurrent sampling
- Lecture 3.2 Survival, hazard, Cox regression.
- Lecture 3.3 Matching on time, HR from conditional logistic regression.
- Exercise 3.1 Inclusive, exclusive and concurrent sampling Illustration in an Excel sheet and in-class demonstration
- Exercise 3.2 Cox, logistic and conditional logistic regression. solutions are here
- Lecture 4.1 Missing data, 2-stage studies, inverse probability weighting
- Lecture 4.2 Optimal sampling of 2-stage data
- Lecture 4.3 Two-stage designs for time-to-event data
- Exercise 4.1: Sampling and analysis of 2-stage data. solutions are here
- for Stata users Exercise 4.2: Optimal sampling in Stata. solutions are here
- for R users Exercise 4.2: Power calculations in R. solutions are here
- Lecture 5.1 RR from case-control data by doubling the cases
- Lecture 5.2 Breaking the time matching; reconstructing the study-base for NCC designs
- Lecture 5.3 Weighted Cox regression of NCC data
- Exercise 5.1: RR from doubling the cases solutions here
- Exercise 5.2: pencil and paper and computation of weights to reconstruct a cohort solutions here and in-class demonstration
- Lecture 6.1 Extension to nested case-control sampling: case-cohort design
- Lecture 6.2 Exposure- enriched controls: counter-matching
- Lecture 6.3 Other controlled designs
- Pearce IJE 2012 Classification of study designs
- Vandenbroucke & Pearce, Int J Epi 2012 case-control basic concepts
- Delgado-Rodriguez & Llorca JECH 2004 Bias
- Babyak_EBMH_2009_Understanding confounding and mediation
- Knol&vanderWeele IntJ Epi 2012 recommendations for presenting effect modification
- Pearce BMJ 2016 Analysis of matched case-control data
- Mansournia, Hernan & Greenland IJE 2013 Matching and causal diagrams
- Mansournia, Jewell & Greenland Eur J Epi 2018 Case-control matching
- Sjolander & Greenland Stat in Med 2013 Ignoring matching in cohort studies
- Knol AJE 2008 What Do Case-Control Studies Estimate
- Watson et al AJE 2018 Risk set matching for hospital acquired infections
- Cain & Breslow AJE 1988 Logistic regression for two-stage studies
- Kivi et al Stat in Med 2005 Two-stage study of H Pylori in schoolchildren
- Spiegelman et al. AJPH 2016 Two-stage design for confounding bias reduction
- Reilly AJE 1996 Optimal sampling_strategies for two-stage studies
- Haneuse et al BMC Med Res Meth 2015 Monitoring & evaluation with 2-phase design
- Graziano Valsecchi & Rebora BMC-MRM 2021 Sampling strategies for a prognostic biomarker
- Franca et al. Pharmacogenomics 2012 A novel (efficient) study design for time-to-event data
- Knol et al CMAJ 2012 Overestimation of RR by OR, alternatives to logistic regression
- Ning, Lam & Reilly BMC Med Res Meth 2022 Estimating RR by doubling the cases
- Delcoigne et al JCE 2017 Breaking the matching in nested case-control data
- Delcoigne et al Stat Meth Med Res 2016 Reusing nested case-control data
- CASE-COHORT
- Laara Meth Mol Biol 2011 Study design for biobank-based epi research
- Langholz & Clayton Env Health Perspec 1994 Countermatching
- Huque et al Genetic Epi 2016 Exposure-enriched case-control
- Borgan&samuelsen Norsk Epi 2003 Review of cohort sampling designs
- SELF-CONTROLLED
- Suissa Epi 1995 The case-time-control design
- Whitaker et al Stat in Med 2006 Tutorial self-controlled case series
- Suissa Epi 2015 Quasi cohort for pharmacoepi
- TEST-NEGATIVE
- Vandenbroucke & Pearce Epi 2019 Test-Negative designs compared to other case-control , and commentary
- Dean AJE 2020 Temporal confounding in test-negative design
- Accorsi et al JAMA Net Open2022 Test-negative study of 3 doses of Covid vaccine
- NEGATIVE CONTROLS
- Lipsitch Epi 2010 Negative controls for detecting confounding and bias, also commentary
- Arnold et al Epi 2016 Negative controls
- Hallas AJE 2021 active comparators for self-controlled designs